A semisynthetic derivative of the Periwinkle plant, vinpocetine was first isolated in Hungary in 1975. It has been mass produced there as a prescription drug since 1978 and is used throughout Eastern Europe as a treatment for cerebrovascular disorders and age-related memory impairment. It is not regulated as a pharmaceutical in the US, where it is sold as a dietary supplement. This is probably one of the most versatile input’s there is; it ties in succinctly with the prior inputs here The Huperzine A Input.
Vinpocetine is readily absorbed from the small intestine following oral administration. It undergoes exten- sive metabolism yielding its main metabolite, apovincaminic acid, which is absorbed from the stomach; due to this extensive metabolism, it has low bioavailability. Under fasting conditions, its absolute bioavailability is 6.7%, and the relative bioavailability under non-fasting conditions has been reported to be 60–100% higher. Following oral administration, vinpocetine readily enters the blood stream from the stomach and gastrointestinal tract and, consequently, passes through the blood-brain barrier and enters the brain which makes Vinpocetine a nice add to any nootropic stack.
Vinpocetine is a very effective input and can be used for memory enhancement; Antioxidant effects, Menopause, Acute Ischemic stroke It is best known as Cerebral vasodilator—it can be a very effective in age related memory impairment or cognitive decline; our memory begins to decline after a particular age it is basically due to damage and the death of neurons—the vinpocetine input has neuroprotective effect; So this input is very effective in neuroplasticity and protecting neurons; Vinpocetine dilates the blood vessels and increase the cerebral blood flow which in turn will optimize cognitation.
40mg/day of vinpocetine has been shown to improve memory and memory scanning speed 30mg/day documented significant improvements in subjects with symptoms of cognitive decline 80mg of Vinpocetine per day significantly reduced reaction times from 610ms to 430ms.
Cerebrovascular diseases include a group of brain disorders associated with cerebral vascularization. The most common disorders include ischemic stroke, hemorrhagic stroke and cerebrovascular anomalies, such as intracranial aneurysms and arteriovenous mal-formations. Differnet disorders of cerebrovascular origin include memory problems, aphasia, apraxia, motordisorders, dizziness, hearing dysfunction (tinnitus and progressive sensorineural hearing loss) and headache. As per a study conducted by the World Health Organization (WHO), cerebrovascular disease is the secondleading cause of death worldwide. The study estimated that cerebrovascular diseases like strokes accounted for 9.6% of all deaths. Furthermore—these diseases are the leading cause of disability in adults; various clinical studies have indicated that the incidence and high mortality of cerebrovascular diseases can be prevented to a large with the simple use of Vinpocetine.
Several different mechanisms have been implicated in the action of vinpocetine. Studies have reported that for the treatment of neurodegenerative conditions—such a Parkinson’s disease and Alzheimer’s disease (AD) Vinpocetine has been suggested to help people with Alzheimer’s disease by enhancing blood flow in the brain—safeguarding brain cells against damage, and inhibiting a substance known as “ phosphodiesterase “ research have gone to suggest that vinpocetine increases the levels of neurotransmitters involved in memory functions, specifically Noradrenaline, Dopamine and Acetylcholine In addition to this, Vinpocetine has been reported to increase the levels of Dopac, the main metabolite of Dopamine in isolated striatum nerve endings.
Research have also shown that Vinpocetine effectively inhibits the reuptake of adenosine, an endogenous anticonvulsant and cerebral protectant, In the latter of which—vinpocetine has been reported to increase cerebral metabolism, which is responsible for the utility of this compound in the treatment of cerebral circulatory disorders, such as Dementia and acute stroke—increased cerebral metabolism is attained through enhanced cerebral flow (vasodilation), the increased consumption of glucose and oxygen in the brain.
If you ever wanted to increase your Long Term Potentiation vinpocetine will work nicely together with Ginko—typically used to drive focus and sharpen memory.
Chronic treatment with vinpocetine for 21 days significantly improved strep- tozotocin-induced learning and memory impairments in rats, reduced the oxidative-nitrosative stress, re- stored the levels of reduced glutathione (GSH) and re- duced acetylcholinesterase activity and lactate dehydrogenase levels;
the increased production of adenosine triphosphate (ATP) in brain cells and increased levels of neurotransmitters involved in memory, which are noradrenaline, dopamine and serotonin—more Ketosis, a true human superpower. #Biohacking #Psychology